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The accumulation is accompanied by the phosphorylation of S oligomers at Ser-129 that triggers apoptosis via rapid retraction of microtubules from the cellular process ( 10 PD and neuroinflammation Microglial cells in the brain are highly sensitive to surrounding microenvironmental changes and cellular damage due to ROS-induced apoptotic neuronal cell death ( The microglial inflammasome describes a unique innate immune system that regulates the inflammatory response in the brain ( Sirts are involved in the regulation of the microglial inflammatory response
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